New research suggests that patients who stop using new slimming jabs like semaglutide or tirzepatide may regain shed pounds much more quickly than those who stop conventional lifestyle regimens.
Research printed in a leading medical journal points out that while overweight people can lose about a fifth of their total mass while on the medication, the weight returns at an estimated rate of nearly a kilo each month after stopping.
"Individuals buying these drugs need to be cognizant of the danger of fast rebound weight gain when the therapy concludes," stated lead investigator Dr. Susan Jebb.
This pace of regain means a reversion to original weight in about 18 months.
Weighing Therapies
The analysis, which examined dozens of trials involving thousands of participants, compared the results of GLP-1 agonists with other pills.
Scientists emphasize that individuals who shed pounds through dieting typically see a slower creep back—around 0.1 kg a month—once they finish.
Understanding the Fast Rebound
Experts believe the mode of action of the drugs explains the accelerated weight return.
The injections mimic a natural hormone called glucagon-like peptide-1, which controls hunger.
"Artificially providing the hormone concentrations far above than the body's typical production could lead to the body to produce less of its endogenous hormone, and could reduce sensitivity to its effects," said Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this GLP-1 'fix' leads to hunger is no longer kept in check, making overeating a significant risk."
A Lifelong Disease?
Medical guidelines advise the jabs for individuals with obesity-related medical conditions, alongside prescribed lifestyle changes.
Many experts argue that, due to the high risk of relapse, the therapy should be considered life-long.
This view is supported by drug manufacturers, who say that the results "emphasize the persistent nature of excess weight," similar to managing diseases like diabetes.
Patient Testimonies
People who have come off the medication explain a sudden return of appetite.
"It was like something that goes on and you're instantly ravenous," said one woman.
The struggle is compounded if patients have not established lasting dietary or behavioural modifications during treatment.
Significant Adoption
Survey data suggest that a significant number of adults in the UK have used these injections in the past year, with desire continuing to grow.
- Adoption is greater among females compared to men.
- The 40s and 50s demographic shows the greatest usage rates.
- A large proportion access the drugs through private prescriptions rather than public health services.
Finally, clinicians emphasize that while the jabs are effective agents for shedding pounds, they are not a standalone solution and long-term success likely depends on combined behavioural management.
